Research

In addition to her clinical work, Dr Saracino is also extensively involved in both clinical and scientific research. Her academic interests and expertise are in the underlying causes, impact and treatments for connective tissue diseases, including the latest treatments for skin lupus, underlying cause and genetics of scleroderma and the impact of skin disease on patients’ quality of life. She continues to publish widely in the scientific medical literature. Amanda is a peer reviewer for the Australasian Journal of Dermatology, as well as European Rheumatology journals.

Examples of Dr Saracino’s current and recent research work include:

  • Investigating the genetic and immunological basis of scleroderma / morphoea
  • Reviewing the latest developments in cutaneous lupus treatments, as well as hydroxychloquine use.
  • Clinical characterization of paediatric and adult onset linear morphoea
  • Describing associations between systemic sclerosis and panniculitis
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Journal Articles

Dr Saracino’s research is regularly published in the top international Dermatology medical journals.

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PRESENTATIONS

Dr Saracino shares her work at international Dermatology conferences.

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WEBSITES

Dr Saracino contributes to patient information websites.

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TEXTBOOKS

Dr Saracino has contributed to latest Dermatology textbooks.

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Journal Articles

Saracino AM, George C, Nihtyanova S and Denton CP. Comparing paediatric and adult onset linear morphoea in a large tertiary referral scleroderma centre. Journal of Scleroderma and Related Disorders.
In Press, June 2020

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Fairley JL, Oon S, Saracino AM, Nikpour M. Management of cutaneous manifestations of lupus erythematosus: A systematic review. Semin Arthritis Rheum. 2020 Feb;50(1):95-127

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Chew CY, Mar A, Nikpour M, Saracino AM. Hydroxychloroquine in dermatology: New perspectives on an old drug. Australas J Dermatol. 2019 Oct 15. doi: 10.1111/ajd.13168

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R Quelhas da Costa, ME Aguirre-Alastuey, DA Isenberg, AM Saracino. Assessment of Response to B-Cell Depletion Using Rituximab in Cutaneous Lupus Erythematosus. JAMA Dermatology Oct 31 2018;

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H. Bhullar, K. Nicholls, R. Martyres, G. Varigos, J. Douglass, AM. Saracino. Mastocytosis: a case series of 107 consecutive patients. British Journal of Dermatology, 2018; 178(1)

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Saracino AM, Denton CP, Orteu CH. The molecular pathogenesis of morphoea: from genetics to future treatment targets’, British Journal of Dermatology. 2017; 177(1): 34-46.

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Saracino AM, Orteu CH. Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treatment with fumaric acid esters. British Journal of Dermatology 2017;176(2):472-80

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Saracino A, Gordon K, Ffolkes L & Mortimer P. Intralymphatic granulomas in lymphoedema secondary to anogenital granulomatosis. Australasian Journal of Dermatology 2012;54(3):50-61.

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Pinder V, Eriyagama S, Saracino A, Wee J. Terra firma-forme dermatosis: another cause of reticulate hyperpigmentation. Clinical & Experimental Dermatology 2012;37(4):446-7

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Saracino A, Kelly R, Lieu D, Chong A. Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up. Australasian Journal of Dermatology 2011;52(3):218-21.

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Presentations

AM Saracino, CP Denton, DJ Abraham.  Unravelling the aetiopathogenesis of morphoea by next generation sequencing of paired skin biopsies.  6th Systemic Sclerosis World Congress, Prague, 2020.

Fairley J, Ong S, Saracino AM, Nikpour M. Management of Cutaneous Manifestations of Lupus Erythematosus: A Systematic Review. American College of Rheumatology 2019 Annual Meeting, Atlanta USA, November 2019.

Saracino AM, Papaioannou I, Denton CP, Abraham DJ. No primary genetic mosaicism detected in whole genome sequencing of linear morphoea epidermis. 16th International Workshop on Scleroderma Research, Cambridge UK, July 2019.

C George, S Nityanova, V Ong, C Orteu, CP Denton, AM Saracino ‘Clinical characterisation of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. Emirates Dermatology Society Annual Conference, Abu Dhabi, November 2018.

AM Saracino, M Nino Leon, JW Taanman, C Fonseca, C Orteu, X Shiwen, D Abraham, C Denton, MPonticos ‘Disease-related site specific metabolic repgramming in linear morphoea fibroblasts’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

M Nino Leon, X Shi Wen, C Fonseca, C Orteu, D Abraham, C Denton, AM Saracino, M Ponticos ‘Cytotoxic T-lymphocyte associated protein-4 expression increased in lesional linear morphoea fibroblasts’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

AM Saracino, C George, V Ong, C Fonseca, C Orteu, C Denton ‘Clinical characteristics of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

AM Saracino, A Mizara, V Ong, C Denton ‘Significant impact of skin disease in systemic sclerosis and patient perceived benefits of specialist dermatology input’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

Saracino AM. ‘Morphoea, clinical update for Dermatologists’. Oxford Regional Dermatology clinical meeting, Oxford University Hospitals NHS Foundation Trust, February 2018.

Saracino AM. ‘What’s new in sclerotic skin disease?’ Southwest Thames Regional Dermatology clinical meeting, St George’s University Hospitals NHS Foundation Trust, November 2017.

C George, S Nityanova, V Ong, C Orteu, CP Denton, AM Saracino ‘Clinical characterisation of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. European Academy of Dermatology and Venerology Congress, Gevena Switzerland, September 2017.

Leeman H, Orteu CH, Saracino AM. ‘Significant psychological impact of skin disease in multisystem connective tissue diseases: experience of a tertiary referral centre’. European Academy of Dermatology and Venerology Congress, Gevena Switzerland, September 2017.

AM Saracino, P Fiandeiro, S Nityanova, V Ong, C Orteu, C Denton, ‘Panniculitis occurring in systemic sclerosis: a report of 16 cases from a large UK systemic sclerosis cohort’. British Association of Dermatology Annual Meeting, Liverpool UK, July 2017.

Leeman H, Saracino AM, Orteu CH, ‘A rare case of PHID syndrome and response to anti-IL6 therapy; an immunopathogenic conundrum’. British Association of Dermatology Annual Meeting, Liverpool UK, July 2017.

Saracino, AM ‘Cutaneous lupus erythematosus; clinical and research update’. Australasian College of Dermatology Annual Scientific Meeting, Sydney Australia, May 2017.

Saracino, AM ‘Morphoea and systemic sclerosis; role of a dermatologist’. Australasian College of Dermatology Annual Scientific Meeting, Sydney Australia, May 2017.

Ramyead S, Saracino AM, Orteu CH ‘Systemic sclerosis and generalised panniculitis’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Clayton J, Saracino AM, Orteu CH, ‘Complex overlap connective tissue disease’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Leeman H, Saracino AM, Orteu CH, ‘Pigmentary hypertrichosis and insulin dependent diabetes mellitus syndrome’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Chinthapalli S, Saracino AM, Orteu CH. ‘Characterisinggeneralised morphoea in adults; disseminated plaque and pansclerotic subtypes’. American Academy of Dermatology Annual Meeting, Orlando USA, March 2017.

Ahmen A, Saracino AM, Orteu CH ‘Significant psychological impact of skin disease in multisystem connective tissue diseases: experience of a tertiary referral centre’ Psychodermatology UK Meeting, British Association of Dermatology, London UK, January 2017.

Chinthapalli S, Saracino AM, Orteu CH. ‘Rituximab induces short-term improvement in disseminated discoid lupus erythematosus lesions in the setting of systemic lupus erythematosus associated nephritis’. 12th Medical Dermatology Meeting, Royal College of Physicians / British Association of Dermatology, London UK, January 2017.

Leeman H, Saracino AM, Orteu CH ‘Pansclerotic morphoea and eosinophilic fasciitis: a spectrum or distinct entities?’ 12th Medical Dermatology Meeting, Royal College of Physicians / British Association of Dermatology, London UK, January 2017.

Flemming C, Saracino AM, Orteu CH, Chan SK ‘Systemic sclerosis or pansclerotic morphoea’ The Royal Society of Medicine, Dermatology Section, London UK, November 2016.

Saracino AM, Orteu CH ‘Rituximab induces short-term improvement in disseminated discoid lupus erythematosus lesions in the setting of systemic lupus erythematosus associated nephritis’ 10th European Lupus Meeting, Venice Italy, October 2016.

Bhullar H, Martyres R, Varigos GA, Douglass J, Saracino A ‘Mastocytosis: A case series of 107 patients and their treatment responses’, Australasian College of Dermatology Annual Scientific Meeting, Perth Australia, May 2016.

Foeldvari I, Baildam E, Blackley M, Boros C, Fligelstone K, Kienast A, Nemkova D, Pain C, Saracino A, Simonini G, Torok KS, Weibel L, Helmus N ‘Proposal of assessment of the activity of juvenile localised scleroderma: results of the consensus meeting in Hamburg, Germany December 2015’, American College of Rheumatology Annual Meeting, Washington USA, November 2016.

Saracino A, Gordon K, Ffolkes L & Mortimer P ‘Intralymphatic granulomas in lymphoedema secondary to anogenital granulomatosis’, The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane Australia, May 2012.

Saracino A, Kelly R, Liew D & Chong A ‘Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up’, The European Association of Dermatology and Venerology 20th Congress, Lisbon Portugal, October 2011.

Saracino A, Kelly R, Liew D & Chong A ‘Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up’ The Australasian College of Dermatologists 43rd Annual Scientific Meeting, Darwin Australia, May 2010.

Websites

Saracino AM, Oakley A. 2017 Morphoea;Dermnet NZ:
https://www.dermnetnz.org/topics/morphoea/

Saracino AM, Denton CP. 2017, updated 2020 Systemic Sclerosis;Dermnet NZ:
https://www.dermnetnz.org/topics/systemic-sclerosis/

Saracino AM. 2016 Cutaneous Lupus Erythematosus, A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/cutaneous-lupus-erythematosus/

Saracino AM, Young L, Mar A, Lee A. 2016 Cutaneous Amyloidosis; A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/cutaneous-amyloidosis/

Young L, Saracino AM, Mar A, Lee A. 2016 Degos Disease; A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/degos-disease/

Textbooks

Saracino AM and Orteu CH. Morphoea management: current approach and future perspectives. Chapter 2 in: Recent advances in dermatology. S Zaheri and I Ali (eds). London: Jaypee UK, 1st Edition, 2019.