Research

In addition to her clinical work, as an academic Dermatologist A/Prof Saracino is also actively involved in research. Amanda’s key academic interests are the underlying causes, impact and treatments for connective tissue diseases, including Lupus and Scleroderma. She is also an investigator in numerous clinical trials for new treatments in skin conditions such as eczema, psoriasis and rosacea at Emeritus Research.

A/Prof Saracino is also an invited peer reviewer for Australasian, US, UK and European Dermatology and Rheumatology journals.

Amanda thoroughly enjoys combining her clinical and research work, and the benefits this can bring to her patients.

Examples of A/Prof Saracino’s current and recent research work include:

Investigating the genetic and immunological basis of scleroderma / morphoea.
Reviewing evidence for the latest in treatment for lupus skin rashes and systemic sclerosis.
Comparing new JAK inhibitors and anti-IL13/4 biologic therapies for severe eczema.
Investigating new topical treatments for psoriasis.

Medical Papers

A/Prof Saracino’s research is regularly published in international Dermatology and Rheumatology medical journals.

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PRESENTATIONS

A/Prof Saracino shares her work and expertise at Dermatology and Rheumatology meetings and conferences.

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WEBSITES

A/Prof Saracino contributes to patient information websites.

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TEXTBOOKS

A/Prof Saracino has contributed to Dermatology textbooks.

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Saracino AM, Kelberman D, Otto GW, Gagunashvili A. Abraham DA, Denton CP. Unravelling morphoea aetiopathogenesis by next-generation sequencing of paired skin biopsies. Arch Dermatol Res. March 2023	View
Saracino AM, Nikpour M. Differentiating Activity From Damage-The Morphological Challenge of Morphea. JAMA Dermatology. February 2023. doi: 10.1001/jamadermatol.2022.6364.	View
Fairley J, Nikpour M, Mack HG, Brosnan M, Saracino AM, Pellegrini M, Wicks IP. How toxic is an old friend? A review of the safety of hydroxychloroquine in clinical practice. Internal Medical Journal. August 2022. DOI: 10.1111/imj.15908.	View
Jerjen R, Nikpour M, Krieg T, Denton CP, Saracino AM. Systemic Sclerosis in adults. Part I: Clinical features and pathogenesis. CME Review Article, Journal of the American Academy of Dermatology. 2022 Nov;87(5):937-954.	View
Jerjen R, Nikpour M, Krieg T, Denton CP, Saracino AM. Systemic Sclerosis in adults. Part 2: Management and therapeutics. CME Review Article, Journal of the American Academy of Dermatology. 2022 Nov;87(5):957-978.	View
Saracino AM, George C, Nihtyanova SI, Denton CP. Comparing paediatric- and adult-onset linear morphoea in a large tertiary-referral scleroderma centre. J Scleroderma Relat Disord. 2021 Feb;6(1):102-108.	View
Fairley JL, Oon S, Saracino AM, Nikpour M. Management of cutaneous manifestations of lupus erythematosus: A systematic review. Semin Arthritis Rheum. 2020 Feb;50(1):95-127	View
Chew CY, Mar A, Nikpour M, Saracino AM. Hydroxychloroquine in dermatology: New perspectives on an old drug. Australas J Dermatol. 2019 Oct 15. doi: 10.1111/ajd.13168	View
R Quelhas da Costa, ME Aguirre-Alastuey, DA Isenberg, AM Saracino. Assessment of Response to B-Cell Depletion Using Rituximab in Cutaneous Lupus Erythematosus. JAMA Dermatology Oct 31 2018;	View
H. Bhullar, K. Nicholls, R. Martyres, G. Varigos, J. Douglass, AM. Saracino. Mastocytosis: a case series of 107 consecutive patients. British Journal of Dermatology, 2018; 178(1)	View
Saracino AM, Denton CP, Orteu CH. The molecular pathogenesis of morphoea: from genetics to future treatment targets’, British Journal of Dermatology. 2017; 177(1): 34-46.	View
Saracino AM, Orteu CH. Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treatment with fumaric acid esters. British Journal of Dermatology 2017;176(2):472-80	View
Saracino A, Gordon K, Ffolkes L & Mortimer P. Intralymphatic granulomas in lymphoedema secondary to anogenital granulomatosis. Australasian Journal of Dermatology 2012;54(3):50-61.	View
Pinder V, Eriyagama S, Saracino A, Wee J. Terra firma-forme dermatosis: another cause of reticulate hyperpigmentation. Clinical & Experimental Dermatology 2012;37(4):446-7	View
Saracino A, Kelly R, Lieu D, Chong A. Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up. Australasian Journal of Dermatology 2011;52(3):218-21.	View

AM Saracino, CP Denton, DJ Abraham. Unravelling the aetiopathogenesis of morphoea by next generation sequencing of paired skin biopsies. 6^th Systemic Sclerosis World Congress, Prague, 2020.

Fairley J, Ong S, Saracino AM, Nikpour M. Management of Cutaneous Manifestations of Lupus Erythematosus: A Systematic Review. American College of Rheumatology 2019 Annual Meeting, Atlanta USA, November 2019.

Saracino AM, Papaioannou I, Denton CP, Abraham DJ. No primary genetic mosaicism detected in whole genome sequencing of linear morphoea epidermis. 16^th International Workshop on Scleroderma Research, Cambridge UK, July 2019.

C George, S Nityanova, V Ong, C Orteu, CP Denton, AM Saracino ‘Clinical characterisation of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. Emirates Dermatology Society Annual Conference, Abu Dhabi, November 2018.

AM Saracino, M Nino Leon, JW Taanman, C Fonseca, C Orteu, X Shiwen, D Abraham, C Denton, MPonticos ‘Disease-related site specific metabolic repgramming in linear morphoea fibroblasts’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

M Nino Leon, X Shi Wen, C Fonseca, C Orteu, D Abraham, C Denton, AM Saracino, M Ponticos ‘Cytotoxic T-lymphocyte associated protein-4 expression increased in lesional linear morphoea fibroblasts’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

AM Saracino, C George, V Ong, C Fonseca, C Orteu, C Denton ‘Clinical characteristics of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

AM Saracino, A Mizara, V Ong, C Denton ‘Significant impact of skin disease in systemic sclerosis and patient perceived benefits of specialist dermatology input’. 5th Systemic Sclerosis World Congress, Bordeaux France, February 2018.

Saracino AM. ‘Morphoea, clinical update for Dermatologists’. Oxford Regional Dermatology clinical meeting, Oxford University Hospitals NHS Foundation Trust, February 2018.

Saracino AM. ‘What’s new in sclerotic skin disease?’ Southwest Thames Regional Dermatology clinical meeting, St George’s University Hospitals NHS Foundation Trust, November 2017.

C George, S Nityanova, V Ong, C Orteu, CP Denton, AM Saracino ‘Clinical characterisation of 133 adults with linear morphoea; comparing paediatric and adult onset disease’. European Academy of Dermatology and Venerology Congress, Gevena Switzerland, September 2017.

Leeman H, Orteu CH, Saracino AM. ‘Significant psychological impact of skin disease in multisystem connective tissue diseases: experience of a tertiary referral centre’. European Academy of Dermatology and Venerology Congress, Gevena Switzerland, September 2017.

AM Saracino, P Fiandeiro, S Nityanova, V Ong, C Orteu, C Denton, ‘Panniculitis occurring in systemic sclerosis: a report of 16 cases from a large UK systemic sclerosis cohort’. British Association of Dermatology Annual Meeting, Liverpool UK, July 2017.

Leeman H, Saracino AM, Orteu CH, ‘A rare case of PHID syndrome and response to anti-IL6 therapy; an immunopathogenic conundrum’. British Association of Dermatology Annual Meeting, Liverpool UK, July 2017.

Saracino, AM ‘Cutaneous lupus erythematosus; clinical and research update’. Australasian College of Dermatology Annual Scientific Meeting, Sydney Australia, May 2017.

Saracino, AM ‘Morphoea and systemic sclerosis; role of a dermatologist’. Australasian College of Dermatology Annual Scientific Meeting, Sydney Australia, May 2017.

Ramyead S, Saracino AM, Orteu CH ‘Systemic sclerosis and generalised panniculitis’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Clayton J, Saracino AM, Orteu CH, ‘Complex overlap connective tissue disease’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Leeman H, Saracino AM, Orteu CH, ‘Pigmentary hypertrichosis and insulin dependent diabetes mellitus syndrome’. The Royal Society of Medicine, Dermatology Section, London UK, March 2017.

Chinthapalli S, Saracino AM, Orteu CH. ‘Characterisinggeneralised morphoea in adults; disseminated plaque and pansclerotic subtypes’. American Academy of Dermatology Annual Meeting, Orlando USA, March 2017.

Ahmen A, Saracino AM, Orteu CH ‘Significant psychological impact of skin disease in multisystem connective tissue diseases: experience of a tertiary referral centre’ Psychodermatology UK Meeting, British Association of Dermatology, London UK, January 2017.

Chinthapalli S, Saracino AM, Orteu CH. ‘Rituximab induces short-term improvement in disseminated discoid lupus erythematosus lesions in the setting of systemic lupus erythematosus associated nephritis’. 12th Medical Dermatology Meeting, Royal College of Physicians / British Association of Dermatology, London UK, January 2017.

Leeman H, Saracino AM, Orteu CH ‘Pansclerotic morphoea and eosinophilic fasciitis: a spectrum or distinct entities?’ 12th Medical Dermatology Meeting, Royal College of Physicians / British Association of Dermatology, London UK, January 2017.

Flemming C, Saracino AM, Orteu CH, Chan SK ‘Systemic sclerosis or pansclerotic morphoea’ The Royal Society of Medicine, Dermatology Section, London UK, November 2016.

Saracino AM, Orteu CH ‘Rituximab induces short-term improvement in disseminated discoid lupus erythematosus lesions in the setting of systemic lupus erythematosus associated nephritis’ 10th European Lupus Meeting, Venice Italy, October 2016.

Bhullar H, Martyres R, Varigos GA, Douglass J, Saracino A ‘Mastocytosis: A case series of 107 patients and their treatment responses’, Australasian College of Dermatology Annual Scientific Meeting, Perth Australia, May 2016.

Foeldvari I, Baildam E, Blackley M, Boros C, Fligelstone K, Kienast A, Nemkova D, Pain C, Saracino A, Simonini G, Torok KS, Weibel L, Helmus N ‘Proposal of assessment of the activity of juvenile localised scleroderma: results of the consensus meeting in Hamburg, Germany December 2015’, American College of Rheumatology Annual Meeting, Washington USA, November 2016.

Saracino A, Gordon K, Ffolkes L & Mortimer P ‘Intralymphatic granulomas in lymphoedema secondary to anogenital granulomatosis’, The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane Australia, May 2012.

Saracino A, Kelly R, Liew D & Chong A ‘Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up’, The European Association of Dermatology and Venerology 20th Congress, Lisbon Portugal, October 2011.

Saracino A, Kelly R, Liew D & Chong A ‘Pyoderma gangrenosum requiring inpatient management: A report of 26 cases with follow-up’ The Australasian College of Dermatologists 43rd Annual Scientific Meeting, Darwin Australia, May 2010.

Saracino AM, Oakley A. Morphoea;Dermnet NZ:
https://www.dermnetnz.org/topics/morphoea/

Saracino AM, Denton CP. Systemic Sclerosis;Dermnet NZ:
https://www.dermnetnz.org/topics/systemic-sclerosis/

Saracino AM. Cutaneous Lupus Erythematosus, A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/cutaneous-lupus-erythematosus/

Saracino AM, Young L, Mar A, Lee A.Cutaneous Amyloidosis; A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/cutaneous-amyloidosis/

Young L, Saracino AM, Mar A, Lee A. Degos Disease; A to Z of skin, Australasian College of Dermatologists:
https://www.dermcoll.edu.au/atoz/degos-disease/

Saracino AM and Orteu CH. Morphoea management: current approach and future perspectives. Chapter 2 in: Recent advances in dermatology. S Zaheri and I Ali (eds). London: Jaypee UK, 1^st Edition, 2019.